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Image Search Results
Journal: International Journal of Molecular Sciences
Article Title: Investigating the Role of 17-Beta Estradiol in the Regulation of the Unfolded Protein Response (UPR) in Pancreatic Beta Cells
doi: 10.3390/ijms25031816
Figure Lengend Snippet: Expression of adaptive UPR markers GRP78/94 in pancreatic sections. Immunofluorescence staining was performed to measure the expression of adaptive UPR markers GRP78/GRP94 in pancreatic islet sections of sham-operated, ovariectomized, ovariectomized supplemented with 17-beta estradiol (E2) female ( A , B ) ApoE −/− :Ins2 +/Akita and female ApoE −/− mice; and male ( C , D ) male ApoE −/− :Ins2 +/Akita supplemented with estrogen (E2) or not. Ovariectomy significantly reduces the expression of GRP78/94 in female ApoE −/− :Ins2 +/Akita mice, while no significant differences are observed in male experimental groups. n = 4–5 per group. * p < 0.05, ** p < 0.01, NS, not significant. Bars represent standard error of the mean (SEM).
Article Snippet: Cell experiments were performed using the
Techniques: Expressing, Immunofluorescence, Staining
Journal: International Journal of Molecular Sciences
Article Title: Investigating the Role of 17-Beta Estradiol in the Regulation of the Unfolded Protein Response (UPR) in Pancreatic Beta Cells
doi: 10.3390/ijms25031816
Figure Lengend Snippet: Expression of adaptive UPR marker PDI in pancreatic islets. Immunofluorescent staining was performed to evaluate the expression of adaptive UPR marker PDI in pancreatic islet sections of sham-operated, ovariectomized, ovariectomized supplemented with 17-beta estradiol (E2) female ( A , B ) ApoE −/− :Ins2 +/Akita and age matched female ApoE −/− mice; and male ( C , D ) male ApoE −/− :Ins2 +/Akita supplemented with 17-beta estradiol or not. n = 4–5 per group. * p < 0.05, ** p < 0.01, NS, not significant. Bars represent standard error of the mean (SEM).
Article Snippet: Cell experiments were performed using the
Techniques: Expressing, Marker, Staining
Journal: International Journal of Molecular Sciences
Article Title: Investigating the Role of 17-Beta Estradiol in the Regulation of the Unfolded Protein Response (UPR) in Pancreatic Beta Cells
doi: 10.3390/ijms25031816
Figure Lengend Snippet: Expression of apoptotic UPR marker GADD153/CHOP in pancreatic sections. Immunostaining was performed to measure the expression of apoptotic UPR marker GADD153/CHOP in pancreatic islet sections of sham-operated, ovariectomized, ovariectomized supplemented with 17-beta estradiol (E2) female ( A , B ) ApoE −/− :Ins2 +/Akita and female ApoE −/− mice; and male ( C , D ) ApoE −/− :Ins2 +/Akita supplemented with estrogen (E2) or not, compared to age matched ApoE −/− controls. Data are expressed as percentage of brown-stained nuclei versus total nuclei in the islet. Ovariectomy significantly increases the expression of the apoptotic marker GADD153/CHOP in female ApoE −/− :Ins2 +/Akita mice to levels similar to those observed in male ApoE −/− :Ins2 +/Akita mice. n = 4–5 per group. * p < 0.05, Bars represent standard error of the mean (SEM).
Article Snippet: Cell experiments were performed using the
Techniques: Expressing, Marker, Immunostaining, Staining